Biochip systems - 02/09/2020 Miniature organs with great potential Dr. Peter Loskill and his team at the Fraunhofer Institute in Stuttgart and the University Hospital of Tübingen are developing what is known as an "organ-on-a-chip" (OoC). An OoC is a microfluidic system that simulates small functional units of organ tissue. OoCs can be used in different ways: in basic and pharmaceutical research as well as in clinical research and application, where they might render many animal experiments…https://biopro-v9-test-gi.xanium.io/en/article/news/miniature-organs-great-potential
TGU Varimol - 24/07/2020 Click chemistry for new medical procedures Using a simple molecular click process, biochemists have been able to connect ring-shaped molecules with each other and couple therapeutically active substances to these molecules. Drugs can thus be specifically delivered to diseased cells and used for imaging processes or biosensors. The Stuttgart-based start-up Varimol is using this new technology to provide its customers with tailored applications that are as simple to use as a kit.https://biopro-v9-test-gi.xanium.io/en/article/news/click-chemistry-new-medical-procedures
Microstructure Technology - 17/07/2020 An electronic nose for many applications Sensory organs are sophisticated masterpieces of nature. That is why humans have often tried to copy them. Be it cameras or microphones - there are technical objects that have always been based on natural models such as the eye or the ear. For a long time, however, no artificial sense of smell has featured in the technical repertoire. Now researchers at the Karlsruhe Institute of Technology (KIT) have developed an electronic nose. It can…https://biopro-v9-test-gi.xanium.io/en/article/news/electronic-nose-many-applications
Dossier - 06/12/2019 Microbiome: human health is closely connected with our microbial communities People have 1.3 times more microorganisms than body cells. This microbial community influences how we digest our food, how active our immune system is, as well as whether we tend to be more anxious or curious. A number of diseases have also been shown to be associated with a disturbed microbiome. Researchers still have a long way to go before the knowledge acquired can be used for developing therapies.https://biopro-v9-test-gi.xanium.io/en/article/dossier/microbiome-human-health-closely-connected-with-microbial-communities
Article - 19/09/2019 Magnetised algae as microrobots for medical and environmental purposes Algae, for most of us, is something that lives in water courses that we occasionally find unpleasant. However, that is to do them a wrong. These extremely versatile and frugal organisms might in future prove to be extremely important. Scientists at the University of Stuttgart are investigating how algae can be used as microrobots in biomedicine and environmental remediation.https://biopro-v9-test-gi.xanium.io/en/article/news/magnetisierte-algen-als-mikroroboter-fuer-medizin-und-umwelt
Article - 05/08/2019 The answer to antibiotic resistance may lie in the microbiome Globally, increasing numbers of bacteria are becoming resistant to common antibiotics. Moreover, many reserve group antibiotics are no longer effective for infections caused by multidrug-resistant pathogens. Researchers in an excellence cluster at the University of Tübingen are investigating an alternative approach to combating bacterial infections. Their goal is to specifically influence the microbiome, the human microbial community.https://biopro-v9-test-gi.xanium.io/en/article/news/answer-to-antibiotic-resistance-may-lie-in-the-microbiome
New edition - 24/05/2019 Tumour metastasis Cancer is usually not curable when metastases have formed in the body. Metastases are often resistant to drugs that have successfully eliminated the primary tumour. The basic features of the complex process of metastasis are now known, but many details still remain elusive. Intensive research activities are focusing on new therapeutic concepts aimed at developing effective anti-metastatic therapies.https://biopro-v9-test-gi.xanium.io/en/article/dossier/tumour-metastasis
Article - 30/01/2019 candidum – computer-assisted enzyme design Industry has been using enzymes for over a hundred years. While it initially had to content itself with natural enzymes, it is now increasingly possible to design tailor-made biocatalysts with specific properties. The start-up company candidum GmbH from Stuttgart promises to achieve this faster than ever before - mostly thanks to accelerated virtual screening.https://biopro-v9-test-gi.xanium.io/en/article/news/candidum-computer-assisted-enzyme-design
Expert interview - 16/01/2019 Cybersecurity is an important issue for the pharmaceutical industry In an increasingly interconnected world, the pharmaceutical and biotechnology sectors need to be aware of cybersecurity threats in manufacturing. We talked about these threats with Holger Mettler who is in charge of computer system validation and cybersecurity at Exyte (formerly M + W), a global enterprise that designs, engineers and constructs complex manufacturing facilities and buildings for the life sciences industry.https://biopro-v9-test-gi.xanium.io/en/article/news/cybersecurity-is-an-important-issue-for-the-pharmaceutical-industry
Article - 10/01/2019 Stocktaking and recommendations for action: the BBAW’s fourth gene technology report In the new gene technology report, the interdisciplinary working group of the Berlin-Brandenburg Academy of Sciences (BBAW) takes stock of gene technology developments in Germany during the past few decades, and discusses the societal, legal and ethical challenges associated with these technologies in the future. The report is highly topical due to the controversy surrounding the ruling of the European Court of Justice on CRISPR/Cas9 genome…https://biopro-v9-test-gi.xanium.io/en/article/news/stocktaking-and-recommendations-for-action-the-bbaws-fourth-gene-technology-report
Dossier - 14/06/2016 CRISPR/Cas – genome editing is becoming increasingly popular The number of publications and patents that involve the CRISPR/Cas system has been increasing exponentially since the technique was first described a few years ago. The increase in funding for projects involving CRISPR/Cas also demonstrates how powerful this new method is. The targeted modification of genomes (also called gene or genome editing) using CRISPR/Cas is extraordinarily accurate and also has the potential to cure hereditary diseases. https://biopro-v9-test-gi.xanium.io/en/article/dossier/crisprcas-genome-editing-is-becoming-increasingly-popular
The Baden-Württemberg healthcare industry Company foundation https://biopro-v9-test-gi.xanium.io/en/location/start-up
Dossier - 10/11/2014 Cell and gene therapies from bench to bedside https://biopro-v9-test-gi.xanium.io/en/article/dossier/cell-and-gene-therapies-from-bench-to-bedside
Dossier - 16/06/2014 Biotechnology as a tool for the production of food Biotechnology opens up numerous opportunities for the food industry. The targeted use of biotechnological methods can help reduce the quantity and number of unhealthy ingredients in foods as well as degrade allergenic substances. Genomic research and targeted breeding also greatly facilitate progress in agriculture. Food biotechnology therefore contributes significantly to saving resources, optimising harvest yields and producing better foods.https://biopro-v9-test-gi.xanium.io/en/article/dossier/biotechnology-as-a-tool-for-the-production-of-food
Dossier - 31/03/2014 Peptides diverse molecules of life Peptides exist in all organisms, wherever there are cells. The range of their physiological functions is huge. Biologically active peptides can act as hormones, neurotransmitters, growth factors as well as toxins and antibiotics. This is what makes them highly interesting drug leads. They are used for the treatment of autoimmune diseases, cancer and other diseases. Peptides are gaining in importance as candidates for drugs.https://biopro-v9-test-gi.xanium.io/en/article/dossier/peptides-diverse-molecules-of-life
Dossier - 02/12/2013 RNA interference confidence is returning The 15-year history of RNA interference is not short on dramatic effects. It begins with the unexpected discovery and publication of the process of post-transcriptional gene silencing in 1998 for which the two Americans Andrew Fire and Craig Mello were awarded the Nobel Prize in Physiology or Medicine just eight years after their discovery. In 2001 Thomas Tuschl succeeded in switching off genes in human cells with small synthetic pieces of RNA…https://biopro-v9-test-gi.xanium.io/en/article/dossier/rna-interference-confidence-is-returning
Dossier - 15/10/2013 Adult stem cells hope for regenerative therapies Adult stem cells have the lifelong ability to generate new specialised cells. They secure the continuous replenishment of cells therefore enabling the constant replacement of dying cells with new ones. Progress in the characterisation isolation and specific differentiation of adult stem cells over recent years raises hopes for the future use of the cells in the therapy of degenerative diseases. Knowledge about adult stem cells also has the…https://biopro-v9-test-gi.xanium.io/en/article/dossier/adult-stem-cells-hope-for-regenerative-therapies
Dossier - 01/07/2013 Electrophysiology from cardiac pacemakers to drug discovery Electrochemical reactions are involved in many processes in the human organism. Electrophysiology is the study of the central processes of electrical and chemical interaction and communication between neurons and muscle cells, including the transmission and processing of signals in the nerves and the subsequent contraction of the muscles. For example, electrophysiology studies examine the rhythm which which our heart pumps blood through the body.https://biopro-v9-test-gi.xanium.io/en/article/dossier/electrophysiology-from-cardiac-pacemakers-to-drug-discovery
Dossier - 13/05/2013 The human proteome the next major goal The “Human Proteome Project”, a ten-year global initiative that is making a systematic effort to map all human proteins, has moved from the planning to the experimental stage. How significant and how effective the project will be depends on how much the resources offered are used by proteome researchers and on the data that the researchers bring into the project.https://biopro-v9-test-gi.xanium.io/en/article/dossier/the-human-proteome-the-next-major-goal
Dossier - 05/11/2012 Cancer basic research successes and trends Science is approaching cancer treatment by using new systems biology approaches and setting up large-scale multidisciplinary projects such as the International Cancer Genome Consortium. Progress in genome, epigenome and gene expression analyses of cancer cells, new insights into the regulation and interaction of cells gained in cooperation with stem cell research and virus research contributes to gaining a causal understanding of cancer.https://biopro-v9-test-gi.xanium.io/en/article/dossier/cancer-basic-research-successes-and-trends
Dossier - 08/10/2012 Marine biotechnology unknown sources of hope from the depths of the sea Biotechnological methods are used to investigate marine life and the results obtained from these investigations advance research in the fields of medicine and energy and into substances used as food supplements and cosmetics. The area of marine biotechnology is fairly diverse. Although it is not on the coast even the southern German state of Baden-Württemberg is involved in marine biotechnology.https://biopro-v9-test-gi.xanium.io/en/article/dossier/marine-biotechnology-unknown-sources-of-hope-from-the-depths-of-the-sea
Dossier - 01/10/2012 Systems biology understanding complex biological systems Systems biology studies complex interactions within biological systems on the genome proteome and organelle level. Many techniques from the fields of systems theory and associated fields can be used to gain an understanding of the behaviour and biological mechanisms of cellular systems.https://biopro-v9-test-gi.xanium.io/en/article/dossier/systems-biology-understanding-complex-biological-systems
Dossier - 23/07/2012 Extremophilic bacteria Extremophilic bacteria love it hot, sour or salty, toxic substances like heavy metals also do them good and even give them energy. As molecular and systems biology techniques get better and better, industry is also becoming increasingly interested in these exotic organisms. What potential does knowing the biochemistry of extremophilic bacteria have for the pharmaceutical, cosmetics and sanitary articles industries? https://biopro-v9-test-gi.xanium.io/en/article/dossier/extremophilic-bacteria
Dossier - 12/03/2012 Regenerative medicine makes use of patients own resources Die Regenerative Medizin bietet neue Therapieoptionen quer durch die ärztlichen Fachgebiete. Zumeist sind es zellbasierte Verfahren und sie werden häufig mit innovativen Biomaterialien kombiniert. Regenerative Therapien vereinen Know-how aus den Biowissenschaften mit moderner Medizintechnik und sie profitieren von den Fortschritten in den Ingenieur- und Materialwissenschaften.https://biopro-v9-test-gi.xanium.io/en/article/dossier/regenerative-medicine-makes-use-of-patients-own-resources
Dossier - 23/01/2012 The neurosciences In recent years, the neurosciences have increasingly made the leap from a purely basic science to applied research. Despite all this, basic research in south-west Germany is more diverse than ever. The discipline still has a number of breakthroughs to look forward to. The brain remains the most enigmatic human organ and one of the fascinating mysteries of the 21st century.https://biopro-v9-test-gi.xanium.io/en/article/dossier/the-neurosciences
