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  • Press release - 04/05/2023

    Gamma delta T cells can fight aggressive breast cancer

    Triple-negative breast cancer (TNBC) is the most aggressive and deadly form of breast cancer with limited treatment options. Tumor growth and relapse of TNBC are driven by breast cancer stem cells, and improved therapies that can eliminate those hardy cells are urgently needed. Researchers from the University of Frieburg discovered that coordinated differentiation and changes in the metabolism of breast cancer stem cells make them invisible for…

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/gamma-delta-t-cells-can-fight-aggressive-breast-cancer
  • Press release - 21/04/2023

    New research building for engineering life-inspired molecular systems

    Heidelberg University is to acquire a research building to develop innovative engineering science strategies and technologies on the basis of life-inspired molecular systems. The German Science and Humanities Council has now expressed its backing for the idea with an outstanding rating. This recommendation is the crucial precondition for a new building on the university campus Im Neuenheimer Feld.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/new-research-building-engineering-life-inspired-molecular-systems
  • Press release - 06/04/2023

    Alternative glucose breakdown ensures the survival of cancer cells

    A key enzyme in sugar metabolism is inactivated particularly easily and efficiently by oxidative stress. Scientists at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now shown that with this oxidation, cells switch to an alternative sugar breakdown pathway and can thus escape oxidative stress. Cancer cells in particular benefit from this mechanism, which can also protect them from therapy-related damage.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/alternative-glucose-breakdown-ensures-survival-cancer-cells
  • Development of anti-tumour agents - 20/03/2023 Drawing of the ER membrane with Sec61 channel to which the B-306 molecule binds. A pink arrow illustrates the calcium release into the cytosol.

    Targeting the protective shield of cancers

    Cancer cells have different mechanisms to help them escape destruction by the immune system. Solid tumours, for example, are often surrounded by a protective layer of lactate, which has a strong immunosuppressive effect. WMT AG from Heidelberg is developing small drug molecules that reduce lactate production and thus make cancer cells vulnerable to immune system attacks.

    https://biopro-v9-test-gi.xanium.io/en/article/news/targeting-protective-shield-cancers
  • Press release - 13/03/2023

    AI and multispectral imaging facilitate keyhole surgery

    How can camera images be used during minimally invasive surgeries to assess whether the operated organ is sufficiently perfused with blood? Scientists from the German Cancer Research Center (DKFZ) and the Städtisches Klinikum Karlsruhe have now succeeded in automatic monitoring of ischemia during a kidney surgery using only the optical properties of the tissue and not relying on injection of contrast agent.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/ki-und-moderne-bildgebung-erleichtern-schluesselloch-chirurgie
  • Cytolytics GmbH - 14/02/2023 Colour photo of Can (left) and Serina (right) Pinar

    Bioinformatics meets medical diagnostics and drug development

    The start-up company Cytolytics from Tübingen has developed a robust and user-friendly software platform that uses machine learning for the automated analysis of cells. This is beneficial in areas such as cancer diagnostics and the development of new pharmaceutically active substances.

    https://biopro-v9-test-gi.xanium.io/en/article/news/bioinformatics-meets-medical-diagnostics-and-drug-development
  • Press release - 03/02/2023

    Health + Life Science Alliance Heidelberg Mannheim officially founded

    Non-profit limited liability company creates institutional framework for interdisciplinary research collaboration, innovative technology development and outstanding healthcare in the Rhine-Neckar region.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/offizielle-gruendung-der-health-life-science-alliance-heidelberg-mannheim
  • Press release - 24/01/2023

    What keeps the immune defense in brain tumors functional

    Cancer immunotherapies often fail because the immune cells are paralysed by immunosuppressive conditions in the tumor. Scientists from Heidelberg, Mannheim and Tel Aviv have now shown on tissue samples from patients as well as on tumor models in mice that the functionality of the immune defence depends decisively on certain helper cells.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/was-die-abwehrzellen-hirntumoren-funktionsfaehig-haelt
  • Press release - 23/01/2023

    Brain stem cells are contolled by interferon during the entire lifetime

    Interferons represent the first line of defence against viral infections and are at the same time an important cause of the age-related loss of function of brain stem cells. Scientists from the German Cancer Research Center (DKFZ) and the University of Heidelberg have now shown in mice that interferon regulates the activity and self-renewal of brain stem cells throughout life.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/hirnstammzellen-lebenslaenglich-unter-interferon-kontrolle
  • Press release - 20/01/2023

    Czech Inventor Award for Martina Benešová-Schäfer

    With the "Česká Hlava" awards, the Czech government has been honoring the country's most brilliant minds every year since 2002 and recognizing exceptional achievements in research, development and innovation. Martina Benešová-Schäfer of the German Cancer Research Center was among the six laureates honored in 2022 at Charles University in Prague.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/tschechischer-erfinderpreis-fuer-martina-benesova-schaefer
  • Press release - 17/01/2023

    Blood stem cells: not in charge in an emergency!

    After infections or blood loss, the body must compensate for the loss of blood cells as quickly as possible. This has long been considered the task of the hematopoietic stem cells in the bone marrow. But scientists at the German Cancer Research Center (DKFZ) have now discovered in mice that a certain population of progenitor cells takes over this task: This accelerates the regeneration of the blood cells.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/blood-stem-cells-not-charge-emergency
  • Press release - 17/01/2023

    Endogenous molecule protects from life-threatening complications after stem-cell transplantation

    Acute Graft-versus-host disease (GvHD) is a life-threatening complication after leukemia treatment with allogeneic stem cell transplantation i.e. the transplantation of cells from another person. GvHD occurs when the transplanted immune cells are overly active and damage the receiving patient's healthy tissue. Researchers found that an endogenous molecule can mitigate this misdirected immune response.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/koerpereigenes-molekuel-schuetzt-vor-lebensbedrohlichen-komplikationen-nach-stammzelltransplantation
  • Value-based healthcare - 11/01/2023 Portrait photo of friendly smiling man with short gray hair and glasses wearing a suit.

    High-quality healthcare pays off

    High-quality medical treatment is not only worthwhile for ill persons. The Division of Health Economics at the German Cancer Research Center in Heidelberg, headed up by Prof. Dr. Michael Schlander, together with researchers from Dresden, has carried out a cost-effectiveness analysis that shows that certified colon cancer centres provide not only better but also more cost-effective care than other clinics.

    https://biopro-v9-test-gi.xanium.io/en/article/news/high-quality-healthcare-pays
  • Press release - 20/12/2022

    Enzyme inhibition promotes bone formation and curbs the development of bone metastases

    In our bones, specialized cells called osteoblasts are responsible for building up bone substance. A team of researchers led by scientists from the DKFZ-Hector Cancer Institute at the University Medical Center Mannheim* and the University Medical Center Hamburg Eppendorf has now identified an enzyme that controls the activity of osteoblasts.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/enzyme-inhibition-promotes-bone-formation-and-curbs-development-bone-metastases
  • Press release - 20/12/2022

    New approach prevents rejection of transplanted organs

    Inhibition of a protein complex in cells of the immune system prevents rejection of transplanted organs – this has been shown in a study by immunologists from the University of Konstanz, the Biotechnology Institute Thurgau (BITg) and Chongqing Cancer University Hospital.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/new-approach-prevents-rejection-transplanted-organs
  • Press release - 14/12/2022

    New drug for metastatic prostate cancer now also approved in Europe

    On December 13, 2022, the European Commission granted approval to a drug against metastatic prostate cancer whose active ingredient was developed under the leadership of the German Cancer Research Center (DKFZ) in collaboration with Heidelberg University Hospital and Heidelberg University. The drug can significantly improve the survival chances of patients.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/neues-medikament-gegen-metastasierten-prostatakrebs-nun-auch-europa-zugelassen
  • Neurodegenerative diseases - 12/12/2022 Darstellung mehrerer Neuronen mit langen Zellfortsätzen, zwischen denen sich kugelförmige Beta-Amyloid-Aggregate befinden. Die  Zellkörper sind von pTau-Fibrillen durchzogen.

    Blood-based biomarkers allow the early prediction of Alzheimer's risks

    Most dementia diseases develop insidiously and are only detected at an advanced stage. Researchers at the University of Heidelberg and the German Cancer Research Center (DKFZ) have now identified the glial fibre acidic protein (GFAP) in the blood as a promising biomarker that can be used to determine an increased risk of developing Alzheimer's disease up to 17 years before diagnosis.

    https://biopro-v9-test-gi.xanium.io/en/article/news/blood-based-biomarkers-allow-early-prediction-alzheimers-risks
  • Press release - 09/12/2022

    Epigenetic emergency switch improves defense against infections

    During infections, the hematopoietic system switches from normal to emergency mode. This improves the defense against the pathogens. Scientists at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now found an epigenetic switch in blood stem cells and progenitor cells of mice that can trigger the switch from one mode to the other.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/epigenetic-emergency-switch-improves-defense-against-infections
  • Funding

    EU4Health Programme (EU4H) – Action Grants 2022

    Funding programme, Funded by: European Union, sb_search.searchresult.label.programSubmissionDate: 21/02/2023
    https://biopro-v9-test-gi.xanium.io/en/database/funding/eu4health-programme-eu4h-action-grants-2022
  • Press release - 24/11/2022

    Green chemistry: BAM investigates pharmaceutical production without solvents and CO2 emissions

    The Bundesanstalt für Materialforschung und -prüfung (BAM) is developing a more sustainable process to produce active pharmaceutical ingredients in a major EU project: The pilot project is intended to demonstrate the advantages of mechanochemistry for more environmentally friendly and CO2-neutral pharmaceutical production.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/gruene-chemie-bam-erforscht-arzneimittelproduktion-ohne-loesungsmittel-und-co2-ausstoss
  • Press release - 15/11/2022

    Silicone Sponge Captures Unknown Bacteria

    From human intestines to the bottom of the sea: Microorganisms populate nearly any habitat, no matter how hostile it is. Their great variety of survival strategies is of huge potential in biotechnology. Most of these organisms, however, are unknown, because they cannot be cultivated.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/silikonschwamm-spuert-unbekannte-bakterien-auf
  • Press release - 09/11/2022

    New Molecular Microscopy Uncovers how Breast Cancer Spreads

    Researchers have created a tool that maps how breast cancer grows in previously unseen detail, and highlights how the cells around the tumour may be the key to controlling the spread of disease. The new technology can trace which populations of breast cancer cells are responsible for the spread of the disease, and for the first time highlights how the location of cancer cells could be as important as mutations in tumor growth The new study is…

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/new-molecular-microscopy-uncovers-how-breast-cancer-spreads
  • Press release - 02/11/2022

    The guardian of the (epi-)genome

    Toxicologists from the University of Konstanz have found that the protein p53 continuously protects our cells from tumorigenesis by coordinating important metabolic processes that stabilize their genomes.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/guardian-epi-genome
  • Viral cancer therapy - 26/10/2022 Microscopic image of plaque formation by HSV1 viruses (green fluorescing).

    Therapeutic viruses against tumours and metastases

    Viruses can overcome cell barriers and transfer information to their host cells. They know how to make their host cell’s infrastructure work for them. This makes them excellent biotechnological tools, which a research group from the Fraunhofer IGB in Stuttgart is using to its advantage. The team is developing a therapeutic virus that not only recognises and fights tumours, but also has the potential to reach metastases.

    https://biopro-v9-test-gi.xanium.io/en/article/news/therapeutic-viruses-against-tumours-and-metastases
  • Press release - 25/10/2022

    Three ERC Synergy Grants For Universität Heidelberg Scientists

    Heidelberg University scientists are to receive three ERC Synergy Grants – three highly endowed grants of the European Research Council – for pioneering research projects by several teams working in collaboration.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/three-erc-synergy-grants-universitaet-heidelberg-scientists

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