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  • Press release - 17/01/2023

    Blood stem cells: not in charge in an emergency!

    After infections or blood loss, the body must compensate for the loss of blood cells as quickly as possible. This has long been considered the task of the hematopoietic stem cells in the bone marrow. But scientists at the German Cancer Research Center (DKFZ) have now discovered in mice that a certain population of progenitor cells takes over this task: This accelerates the regeneration of the blood cells.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/blood-stem-cells-not-charge-emergency
  • Press release - 17/01/2023

    Endogenous molecule protects from life-threatening complications after stem-cell transplantation

    Acute Graft-versus-host disease (GvHD) is a life-threatening complication after leukemia treatment with allogeneic stem cell transplantation i.e. the transplantation of cells from another person. GvHD occurs when the transplanted immune cells are overly active and damage the receiving patient's healthy tissue. Researchers found that an endogenous molecule can mitigate this misdirected immune response.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/koerpereigenes-molekuel-schuetzt-vor-lebensbedrohlichen-komplikationen-nach-stammzelltransplantation
  • Neurodegenerative diseases - 12/12/2022 Darstellung mehrerer Neuronen mit langen Zellfortsätzen, zwischen denen sich kugelförmige Beta-Amyloid-Aggregate befinden. Die  Zellkörper sind von pTau-Fibrillen durchzogen.

    Blood-based biomarkers allow the early prediction of Alzheimer's risks

    Most dementia diseases develop insidiously and are only detected at an advanced stage. Researchers at the University of Heidelberg and the German Cancer Research Center (DKFZ) have now identified the glial fibre acidic protein (GFAP) in the blood as a promising biomarker that can be used to determine an increased risk of developing Alzheimer's disease up to 17 years before diagnosis.

    https://biopro-v9-test-gi.xanium.io/en/article/news/blood-based-biomarkers-allow-early-prediction-alzheimers-risks
  • Press release - 09/12/2022

    Epigenetic emergency switch improves defense against infections

    During infections, the hematopoietic system switches from normal to emergency mode. This improves the defense against the pathogens. Scientists at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now found an epigenetic switch in blood stem cells and progenitor cells of mice that can trigger the switch from one mode to the other.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/epigenetic-emergency-switch-improves-defense-against-infections
  • Press release - 25/11/2022

    Praise for Ulm's trauma research from DFG CRC 1149 reaches 3rd funding phase

    What a success for Ulm University and its medical centre! The German Research Foundation (Deutsche Forschungsgemeinschaft; DFG) extends the Collaborative Research Centre (CRC) on Trauma Medicine for the second time. The third funding phase infuses the CRC 1149 'Danger Response, Disturbance Factors and Regenerative Potential after Acute Trauma' with 11.1 million euros.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/praise-ulms-trauma-research-dfg-crc-1149-reaches-3rd-funding-phase
  • Press release - 24/11/2022

    SARS-CoV-2 detection in 30 minutes using gene scissors

    Researchers of the University of Freiburg introduce biosensor for the nucleic acid amplification-free detection of SARS-CoV-2 RNA.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/sars-cov-2-nachweis-30-minuten-mit-der-genschere
  • Start-up Actimi GmbH - 23/11/2022 The photo shows a body scale and the user interface of the app on the tablet. Furthermore, a bag and the ECG measuring device can be seen.

    Real-time telemonitoring of heart failure

    Improved quality of life for patients and lower costs for health insurers: these are the advantages of telemonitoring patients with advanced heart failure. The Stuttgart-based start-up Actimi offers an all-in-one platform for those who treat and those who suffer from the disease.

    https://biopro-v9-test-gi.xanium.io/en/article/news/real-time-telemonitoring-heart-failure
  • Press release - 17/11/2022

    New target for Alzheimer's therapies found

    DZNE researchers discover link between the protein medin and Alzheimer's disease. The protein medin is deposited in the blood vessels of the brains of Alzheimer's patients along with the protein amyloid-β. DZNE Researchers have discovered this so-called co-aggregation. They have now published their observation in the renowned journal Nature.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/new-target-alzheimers-therapies-found
  • Press release - 24/10/2022

    How tumors suppress the development of metastases

    Why do metastases often only appear after the original tumor has been surgically removed? Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the Mannheim Medical Faculty of Heidelberg University have now published an explanation for this phenomenon. They were able to identify a messenger substance of the cancer cells that locally promotes the growth of the primary tumor.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/wie-tumoren-die-entstehung-von-metastasen-unterdruecken
  • Press release - 28/09/2022

    First successful trial for early detection of HPV-related cancer of the pharynx

    Screening trials for the early detection of rare diseases often fail due to insufficient predictive power of the results. For the rare HPV-related cancer of the pharynx, scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) now relied on the combined detection of antibodies against two different viral proteins in a proof-of concept trial.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/erste-erfolgreiche-studie-zur-frueherkennung-von-hpv-bedingtem-krebs-im-rachenraum
  • Hummingbird Diagnostics GmbH - 22/09/2022 Logo-Hummingbird_Signet.jpg

    The great potential of blood-based microRNA analyses

    "The early bird catches the worm", is an apt description of what motivates Hummingbird Diagnostics GmbH from Heidelberg. The medium-sized biotechnology company analyses special biomarkers in blood, so-called microRNAs, in order to diagnose diseases at an early stage and to be able to make forecasts about the course of the disease and the success of therapy.

    https://biopro-v9-test-gi.xanium.io/en/article/news/great-potential-blood-based-microrna-analyses
  • Press release - 21/09/2022

    ERC funding: How to deliver gene therapies to a specific target site?

    With its "Proof of Concept" grants, the European Research Council ERC supports scientists in further developing the commercial potential of their research results. Nina Papavasiliou from the DKFZ is now receiving the prestigious grant for the second time: she wants to advance the development of a "molecular delivery service" that ensures that therapeutic genes reach the right address in the body in a targeted manner.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/erc-funding-how-deliver-gene-therapies-specific-target-site
  • Press release - 09/09/2022

    Breaking down proteins: How starving cancer cells switch food sources

    Cancer cells often grow in environments that are low in nutrients, and they cope with this challenge by switching their metabolism to using proteins as alternative "food". Building on genetic screens, an international team of scientists could identify the protein LYSET as part of a pathway that allows cancer cells to make this switch. Their findings are now published in the journal Science.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/neu-identifiziertes-protein-ermoeglicht-krebszellen-auf-alternative-nahrungsquellen-auszuweichen
  • Press release - 18/08/2022

    When smooth muscle cells lack strength

    University of Tübingen team discovers how malformations of the blood vessels can occur in mice – yielding information with possible ramifications for retinal disease.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/when-smooth-muscle-cells-lack-strength
  • Press release - 04/08/2022

    Inflammation accelerates aging of the hematopoietic system

    In mice, inflammation in early to mid-life leads to a permanent decline in functional blood stem cells, according to a recent publication by scientists from the German Cancer Research Center (DKFZ) and the Stem Cell Institute HI-STEM*. The ability of the blood stem cells to regenerate was suppressed for at least one year after challenge with inflammation.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/inflammation-accelerates-aging-hematopoietic-system
  • RHEACELL GmbH - 28/07/2022 Zeichnerische Umsetzung des Verhältnisses von M1 und M2 Makrophagen mithilfe einer Waage. Im Stadium der Entzündung überwiegen M1 Makrophagen, bei Wundheilung M2 Makrophagen.

    Innovative stem cell therapy for chronic wounds

    Non-healing, chronically inflamed wounds can be very painful and carry the risk of serious infections. The Heidelberg company RHEACELL has developed a unique drug based on ABCB5-positive mesenchymal stem cells that helps reprogramme the relevant immune cells and promote healing.

    https://biopro-v9-test-gi.xanium.io/en/article/news/innovative-stem-cell-therapy-chronic-wounds
  • Organ-on-chip for the analysis of drug effects - 20/07/2022 Zeichnerische Darstellung eines Organ-on-Chip-Systems

    New 3D cell platform allows continuous metabolic monitoring

    Organ-on-chips systems are systems containing miniature tissues grown inside mircrofluidic chips. By integrating microsensors, researchers at the IMTEK Freiburg, together with the RWTH Aachen University Hospital, created a novel variant that allows the measurement of metabolic activity directly on site and in real time. This enables the rapid and detailed analysis of drug effects outside an organism.

    https://biopro-v9-test-gi.xanium.io/en/article/news/new-3d-cell-platform-allows-continuous-metabolic-monitoring
  • AaviGen GmbH: Hope for heart failure - 14/07/2022 Black and white electron microscope image of some virus particles.

    Gene therapy for weakened hearts

    Treating a weak heart – for example after a heart attack – at the GP’s surgery with a single intravenous injection, without causing serious side effects: what sounds almost too good to be true is actually already under development. The Heidelberg-based biotech company AaviGen is working on a platform technology based on adeno-associated viruses that can help introduce therapeutic genes in a highly specific way into diseased heart muscle cells.

    https://biopro-v9-test-gi.xanium.io/en/article/news/gene-therapy-weakened-hearts
  • Press release - 23/06/2022

    Cancer patients receiving immunotherapy: no evidence of increased risk for severe immune complication after COVID-19 vaccination

    Does COVID-19 vaccination increase the risk of cancer patients undergoing therapy with immune checkpoint inhibitors to suffer a dangerous immune complication known as a "cytokine release syndrome"? A team of Heidelberg physicians and scientists has now shown in a clinical study: Increased serum levels of the characteristic cytokines occur frequently in cancer patients, but clinically relevant cases of the dreaded syndrome were not…

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/cancer-patients-receiving-immunotherapy-no-evidence-increased-risk-severe-immune-complication-after-covid-19-vaccination
  • Assay to support the diagnosis of autoimmune diseases - 22/06/2022 Immunkomplexe_sIC-assay_Teaser.jpg

    Tracking down pathogenic immune complexes

    Soluble complexes of antibodies and their target structures circulating in the blood can trigger serious systemic inflammations. Dr. Philipp Kolb and Haizhang Chen from the Institute of Virology at the Freiburg University Medical Centre have developed a sensitive, cell-based test system for detecting these immune complexes. The system can be used to diagnose systemic autoimmune diseases, and also severe cases of COVID-19.

    https://biopro-v9-test-gi.xanium.io/en/article/news/tracking-down-pathogenic-immune-complexes
  • Press release - 20/06/2022

    Protein changes in the liquor indicate inflammatory processes in the brain

    Alzheimer's, Parkinson's and other neurodegenerative diseases are associated with inflammatory processes in the brain. German researchers have succeeded in identifying a group of proteins in the liquor that could provide information about such inflammatory processes. As so-called biomarkers, the proteins could help to better understand disease processes in the future and to test the effect of potential drugs against brain inflammation.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/protein-changes-liquor-indicate-inflammatory-processes-brain
  • Press release - 12/05/2022

    New imaging method makes tiny medical robots visible in the body

    Microrobots have the potential to revolutionize medicine. Researchers at the Max Planck ETH Centre for Learning Systems have now developed an imaging technique that for the first time recognises cell-sized microrobots individually and at high resolution in a living organism. This is an important step towards precise control of the robots and their clinical translation.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/new-imaging-method-makes-tiny-medical-robots-visible-body
  • Company profile: medicalvalues GmbH - 05/05/2022 Laptop mit einer Software-Oberfläche, die in Weiß und teilweise in Violet gehalten ist.

    medicalvalues – best possible diagnostics thanks to AI

    The Karlsruhe-based start-up medicalvalues GmbH wants to use its platform to bring together different clinical data sets and thus enable comprehensive medical diagnostics. Artificial intelligence featuring innovative diagnostic algorithms is used to evaluate the data and generate new insights for laboratories and hospitals.

    https://biopro-v9-test-gi.xanium.io/en/article/news/medicalvalues-best-possible-diagnostics-thanks-ai
  • Press release - 25/04/2022

    Reprogrammed macrophages promote spread of breast cancer

    Metastatic breast cancer cells abuse macrophages, a type of immune cell, to promote the settlement of cancer metastases in the lungs. The reprogrammed macrophages stimulate blood vessel cells to secrete a cocktail of metastasis-promoting proteins that are part of the so-called metastatic niche.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/reprogrammed-macrophages-promote-spread-breast-cancer
  • Press release - 13/04/2022

    Emmy Noether funding for research into drug resistance of blood cancer

    The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) is funding a new Emmy Noether junior research group at the DKFZ for six years with a total of around 2 million euros. The scientists and doctors, who are part of the Clinical Cooperation Unit for Pediatric Leukemia at the KiTZ, are using a new procedure to investigate how cancer cells manipulate the formation of proteins to become resistant to cancer drugs.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/emmy-noether-funding-research-drug-resistance-blood-cancer

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