Drugs consist of molecules developed in the drug laboratory that bind to their target, usually a protein, and thus exert their effect. The actual duration of binding of a drug molecule to its target protein varies depending on the drug. The lifetime of the drug-target complex can play a critical role in the efficacy of a drug, as a long residence time at the target can be crucial for the drug's action in some cases.

Dr. Stefan Schiller and Dr. Matthias Huber from the University of Freiburg’s livMatS Cluster of Excellence have succeeded in developing a muscle solely on the basis of natural proteins. The autonomous contractions of the material, which the researchers presented in the journal Advanced Intelligent Systems, can be controlled with the help of pH and temperature changes.

Viral zoonoses - 24/01/2022

Development of inhibitors that help stop viral zoonoses

Emerging viral infections such as COVID-19 or Zika disease pose an increasing threat to humans. At the Institute of Pharmacy and Molecular Biotechnology (IPMB) at Heidelberg University, Prof. Dr. Christian Klein's research group is developing inhibitors against already known viruses in the hope that these can also be used against new virus variants.

The HUEHOCO GROUP Holding GmbH & Co. KG, a family-owned company from Wuppertal, North Rhine-Westphalia, has acquired a 5 percent stake in carbonauten GmbH. The start-up is in negotiations with further interested parties from Germany and Japan. With the international metal strip refiner HUEHOCO Group, which has sites on 4 continents, the "minus CO2 factory" has acquired its first industrial partner.

microRNA as a prognostic biomarker - 13/01/2022

Heart attack diagnosis: fast and unambiguous thanks to artificial intelligence

People that arrive in emergency rooms with chest pain require swift action in order to rule out a heart attack or to initiate vital life-saving therapy. However, despite many advances, current tests are not yet optimal: they either take hours or produce false-positive results. Researchers at Heidelberg University Hospital are now using AI in an approach that takes microRNAs from a blood sample to specifically diagnose ‘acute coronary syndrome’.

Making important raw materials for fine chemicals out of carbon dioxide really works. As part of the Max Planck collaborative project eBioCO2n, a team of researchers from Fraunhofer IGB have successfully performed a first ever fixation of CO2 via a multi-enzyme enzyme reaction driven by electricity yielding a prospective intermediate for the chemical industry. The process for electro-biocatalytic CO2 fixation was recently published and is…

Protection against game damage - 13/01/2022

Sapling protectors made of domestic wood - simple but effective

Young forest plants need protecting against damage and as a result it’s often hard to miss the colourful plastic tree guard sleeves when out walking in forests. These tree guard sleeves are neither pleasing to the eye nor sustainable. Bernd Schairer UG from Albstadt has developed sapling protectors made of wood that contain no plastics, metals or chemicals, do not require removal and disposal, and are produced in a socially responsible way.

Chitin is the main component of insect carapaces and ensures that they are both stable and flexible. The Chitinfluid research project, funded by the Carl Zeiss Foundation, focuses on the use of chitin in construction and aims to process chitin and its derivatives into sustainable materials. In a hybrid symposium under the auspices of Prof. Sabine Laschat from the University of Stuttgart, the project team discussed the current state of research…

The incidence of colorectal cancers in young adults is increasing. At the same time, the proportion of overweight and obese young people is also on the rise. Whether there is a connection between these two observations, however, was not known until now. Scientists at the DKFZ have now shown that the risk of early colorectal cancer is significantly increased in overweight young people compared to normal-weight peers.

Genetic alterations that promote the development and spread of tumors are difficult to identify. This is especially true for mutations in the non-protein-coding regions of the genome, which include all important regulatory sequences. Scientists at the German Cancer Research Center have now published an algorithm that detects cancer drivers in both the protein-coding and non-coding regions of the genome.

The cochlear implant (CI) is the most successful neural prosthesis worldwide. Thanks to direct stimulation of the auditory nerve, it enables more than half a million people worldwide to hear, even though those affected were born deaf or deafened.

Researchers at Heidelberg University Hospital (UKHD), the German Cancer Research Center (DKFZ) and at the National Center for Tumor Diseases (NCT) Heidelberg have demonstrated for the first time that there is a link between the development of colorectal cancer in individuals with Lynch syndrome and the composition of immune cells in the colorectal mucosa.

The International Agency for Research on Cancer (IARC), an agency of the World Health Organization (WHO), will soon publish the first edition of its classification of childhood cancers. The new WHO classification forms the basis of modern, precise cancer diagnostics for physicians and pediatric oncologists worldwide and is based on the latest international research findings.

Dossier - 16/12/2021

Advanced therapy medicinal products: gene and cell therapies

Novel gene and cell therapies for treating incurable and hereditary diseases have raised high expectations. However, success has so far been limited to the long-established bone marrow transplants involving the administration of haematopoietic stem cells used to treat blood cancer. CAR T-cell therapies have recently emerged as a major new hope in cancer treatment.

For the second time, the nova Institute for Ecology and Innovation is honouring outstanding scientific research that provides sustainable solutions for the cellulose fibre value chain as part of the "International Conference on Cellulose Fibres 2022". The DITF Denkendorf is one of the six nominees.

Plant residues - 14/12/2021

Straw pulp: agricultural residues become sanitary paper products

Straw cannot yet be spun into gold, but in Mannheim, Germany, it is being turned into something else of great value: Essity is the first and only company in Europe to produce toilet paper and kitchen rolls from wheat straw in a new pulp mill. From next year, these sustainable sanitary paper products will be found on supermarket shelves.

Today, the EU Parliament adopted the EU Regulation on Health Technology Assessment (HTA), which includes not only new medicines (including gene and cell therapies), but also medical devices.

A new interdisciplinary research project aims to uncover information that can help decode hereditary colon cancer with the aid of mathematical models. Mathematicians and tumour biologists of Heidelberg University, the Heidelberg Institute for Theoretical Studies, Heidelberg University Hospital, and the German Cancer Research Center are collaborating on the project.

Renewable raw materials and the circular economy in the textile industry - 08/12/2021

Outdoor equipment made from cellulose, castor oil and coffee grounds - functional and durable

VAUDE develops outdoor gear made from natural or recycled materials that are harmless to people and the environment while protecting against the wind and rain. The company relies on renewable raw materials, biobased plastics and the circular economy.

Once again Germany's no. 1 in agricultural research as well as food and nutritional science: The University of Hohenheim in Stuttgart. It remains in 7th place in Europe and comes in 34th place worldwide. This is the result of the latest Best Global Universities ranking by the U.S. magazine U.S. News & World Report in cooperation with Clarivate.

The development of immunotherapies against blood cancer could be more successful if T cells are activated moderately rather than excessively. Scientists from the German Cancer Research Center have now been able to show this in mice: If the researchers blocked a cytokine that slows down the immune system, the T cells became exhausted and failed in the fight against leukemia.