University of Tübingen team discovers how malformations of the blood vessels can occur in mice – yielding information with possible ramifications for retinal disease.

In mice, inflammation in early to mid-life leads to a permanent decline in functional blood stem cells, according to a recent publication by scientists from the German Cancer Research Center (DKFZ) and the Stem Cell Institute HI-STEM*. The ability of the blood stem cells to regenerate was suppressed for at least one year after challenge with inflammation.

A centre for model-based artificial intelligence has been set up at Heidelberg University to link mathematical modelling methods with information processing in neuronal networks. The Carl Zeiss Foundation (CZS) is funding the CZS Heidelberg Center for Model-Based AI with five million euros over a period of six years.

RHEACELL GmbH - 28/07/2022

Innovative stem cell therapy for chronic wounds

Non-healing, chronically inflamed wounds can be very painful and carry the risk of serious infections. The Heidelberg company RHEACELL has developed a unique drug based on ABCB5-positive mesenchymal stem cells that helps reprogramme the relevant immune cells and promote healing.

Carbon sequestration - 28/07/2022

Carbon farming - climate protection on agricultural land?

Agriculture plays a key role in helping to achieve European climate targets. Central to this goal are measures that are collectively referred to as carbon farming and are often used for offsetting greenhouse gas emissions. Two Baden-Württemberg companies - CarboCert and Carbonfuture - are active in addressing the challenges and potentials of carbon farming.

In Provence, the lavender fields are in full bloom again. This blaze of color may soon also be seen in Baden-Württemberg. In a joint research project, the German Institutes of Textile and Fiber Research Denkendorf (DITF), the University of Hohenheim and the company naturamus are testing suitable lavender varieties and developing energy-efficient methods for producing essential oil from them.

Organ-on-chip for the analysis of drug effects - 20/07/2022

New 3D cell platform allows continuous metabolic monitoring

Organ-on-chips systems are systems containing miniature tissues grown inside mircrofluidic chips. By integrating microsensors, researchers at the IMTEK Freiburg, together with the RWTH Aachen University Hospital, created a novel variant that allows the measurement of metabolic activity directly on site and in real time. This enables the rapid and detailed analysis of drug effects outside an organism.

AaviGen GmbH: Hope for heart failure - 14/07/2022

Gene therapy for weakened hearts

Treating a weak heart – for example after a heart attack – at the GP’s surgery with a single intravenous injection, without causing serious side effects: what sounds almost too good to be true is actually already under development. The Heidelberg-based biotech company AaviGen is working on a platform technology based on adeno-associated viruses that can help introduce therapeutic genes in a highly specific way into diseased heart muscle cells.

Biotech in outer space - 06/07/2022

yuri, a space start-up: weightlessness for commercial research

Growing cells without the effect of gravity could revolutionise drug development. A start-up called yuri on Lake Constance enables made-to-measure experiments on the ISS for stem cells, artificial organs, surfaces and materials. On board the next mission are some mini-cell labs from Berlin's Charité and Goethe University Frankfurt.

Hearing loss - 29/06/2022

Innovative micro loudspeaker brings back hearing

Hearing loss often severely restricts the lives of those affected and can only be partially reversed with conventional hearing aids. The innovative hearing aid developed by Vibrosonic GmbH from Mannheim transmits sound vibrations directly to the eardrum and can thus almost completely restore the natural hearing experience.

Mitochondria are the power plants of cells, and they contain their own genetic material and RNA molecules. Scientists from the German Cancer Research Center (DKFZ) have now discovered that certain modifications in mitochondrial RNA boost the invasive spread of cancer cells by supporting protein synthesis in mitochondria.

Paludiculture as a beacon of hope for the climate - 28/06/2022

Peatlands as CO2 reservoirs: simultaneous renaturation and use

Peatlands store more carbon dioxide than any other ecosystem in the world. However, when drained, they become a climate-damaging source of CO2. The management of wet peatlands reveals exciting solutions, with market potential in the areas of local heating, insulation, packaging and even peat substitution.

Does COVID-19 vaccination increase the risk of cancer patients undergoing therapy with immune checkpoint inhibitors to suffer a dangerous immune complication known as a "cytokine release syndrome"? A team of Heidelberg physicians and scientists has now shown in a clinical study: Increased serum levels of the characteristic cytokines occur frequently in cancer patients, but clinically relevant cases of the dreaded syndrome were not…

Press release - 22/06/2022

Concluding conference of the ARDIA-Net Interreg project

On May 11, the concluding conference of the ARDIA-Net Interreg project took place with 18 in-person attendees in Milan and 18 online participants. The programme for the half-day event included presentations and two panels on the project results as well as discussions on further cross-regional cooperation.

Assay to support the diagnosis of autoimmune diseases - 22/06/2022

Tracking down pathogenic immune complexes

Soluble complexes of antibodies and their target structures circulating in the blood can trigger serious systemic inflammations. Dr. Philipp Kolb and Haizhang Chen from the Institute of Virology at the Freiburg University Medical Centre have developed a sensitive, cell-based test system for detecting these immune complexes. The system can be used to diagnose systemic autoimmune diseases, and also severe cases of COVID-19.

Scientists from the 2. Physics Institute at the University of Stuttgart and the Max Planck Institute for Medical Research were now able to take the next step towards synthetic cells: They introduced functional DNA-based cytoskeletons into cell-sized compartments and showed functionality. The results were recently published in Nature Chemistry.

Alzheimer's, Parkinson's and other neurodegenerative diseases are associated with inflammatory processes in the brain. German researchers have succeeded in identifying a group of proteins in the liquor that could provide information about such inflammatory processes. As so-called biomarkers, the proteins could help to better understand disease processes in the future and to test the effect of potential drugs against brain inflammation.

Renaturalised peatlands as carbon dioxide stores - 14/06/2022

Peatlands as a climate protection factor - binding CO2 instead of releasing it

All intact peatlands on our planet store twice the amount of CO2 as all forests. Peatlands are indispensable for preventing and mitigating the effects of climate change. The only problem is that 95 percent of Germany's peatlands have been drained, and thus release around 7 percent of Germany’s total CO2 emissions into the atmosphere. Rewetting is therefore imperative for the climate, the environment and biodiversity – and economically…

Robot arm for greater accuracy - 08/06/2022

guidoo: robotic assistance for fast and precise biopsies

Needle-based procedures through the skin, such as biopsies of internal organs, not only require a great deal of skill and experience, but they also take time. Fraunhofer IPA Mannheim, together with BEC GmbH from Pfullingen, is developing a robotic surgical assistance system that supports the correct positioning and angulation of a needle with the help of a guide sleeve. This significantly speeds up the procedure while maintaining precision.

The nuclease Cas13b associated with the CRISPR gene scissors, which is an enzyme that degrades nucleic acids, has the potential to be used in the future in hereditary diseases to switch off unwanted genes. In the fight against infections, this nuclease is also being researched as an antiviral agent, as Cas13b can specifically intervene in the genetic material of viruses and render them harmless.

Dr. Nicole Hoffmeister-Kraut, Minister of Economic Affairs, Labour and Tourism of Baden-Württemberg, together with Freiburg’s Mayor Martin Horn, gives the go-ahead for the construction project on the Georges-Köhler-Allee.

Bakteriocins - 24/05/2022

New antibiotic alternatives from soil bacteria

Bacteria are not the greatest of friends among themselves: many release antimicrobial substances into their environment in order to gain an advantage in their ecological niche. Researchers at the University of Ulm are making use of such bacteriocins by creating a genetically modified soil bacterium that can be used as a biotechnological platform organism to produce alternatives to antibiotics in pure form and in large quantities. The fact this…

Lentil cultivation in a producers’ association - EIP-AGRI Rhizo-Linse project - 23/05/2022

From cultivation to market – lentils from the Swabian Alb

Complicated cultivation, fluctuating yields and complex cleaning: Leisa – as lentils are called in Swabian – are demanding. So to produce lentils economically, 130 farmers in the Swabian Alb have joined forces and set up the organic producers’ association Alb-Leisa. Their lentil harvests are processed and marketed by a company called Lauteracher Alb-Feld-Früchte.

The construction industry consumes large amounts of energy resources and produces tons of waste. At the Solar Decathlon Europe 21/22 university competition, students and researchers from KIT are eager to demonstrate that the building sector is already compatible with a functioning circular economy. The task of the interdisciplinary “RoofKIT” team is to convert previously unused roofs of buildings into usable spaces.