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  • Press release - 22/05/2024

    Stretched beyond the limits of the cell: the molecular biomechanics of collagen

    Together with colleagues from Israel and USA, HITS researcher Frauke Gräter investigates the effects of physical force on the collagen protein in two different animal model systems. Their goal is to measure the effects of mechanoradicals on the integrity of the tissue and the well-being of the organism, with impact on health and aging.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/stretched-beyond-limits-cell-molecular-biomechanics-collagen
  • Press release - 17/04/2024

    Cell Biology: Molecular Code Stimulates Pioneer Cells to Build Blood Vessels in the Body

    Cardiovascular diseases, including stroke and myocardial infarction, are the world's leading causes of mortality, accounting for over 18 million deaths a year. A team of KIT researchers has now identified a new cell type in blood vessels responsible for vascular growth. This discovery may allow for novel therapeutic strategies to treat ischemic cardiovascular diseases, i.e. diseases that are caused by reduced or absent blood flow.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/zellbiologie-molekularer-code-regt-pionierzellen-zum-aufbau-von-blutgefaessen-im-koerper
  • Neurosciences - 28/02/2024 A microscopic image shows how a brain organoid grows around and through the mesh microelectrode array.

    Mesh microelectrode arrays: research with brain organoids on a new level

    How does the brain work? Brain organoids are derived from pluripotent stem cells and regarded as valuable model systems that can depict some aspects of neurological functioning. Dr. Peter Jones from NMI together with Dr. Thomas Rauen from the MPI for Molecular Biomedicine in Münster, has taken organoid research to a new level. His novel mesh microelectrode array (Mesh-MEA) greatly improves the growth and electrophysiological analysis of tissue.

    https://biopro-v9-test-gi.xanium.io/en/article/news/mesh-microelectrode-arrays-research-brain-organoids-new-level
  • Press release - 30/10/2023

    New research group: construction of tissue in laboratory

    An interdisciplinary research group combining mechanical engineering and biotechnology has taken up its work at the Institute for Molecular Systems Engineering and Advanced Materials (IMSEAM) of Heidelberg University. The team under the direction of Dr Kai Melde will pursue an innovative approach to biofabrication – 3D cell culture using ultrasound. Tools are being developed that can be used as an alternative to or enhancement for 3D printing.

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/neue-forschungsgruppe-konstruktion-von-gewebe-im-labor
  • High-resolution microscopy technology bypassing the diffraction limit - 26/10/2023 The top picture shows a common microscope with a screen on the left and an upright, shoebox-sized black box to the right. The lower picture shows a large, flat device with a state-of-the-art microscopy unit and a screen to the right.

    From micro- to nanoscope

    It has long been impossible to distinguish objects closer than 200 nanometres using light microscopes. However, novel devices developed by a company called abberior Instruments GmbH, which use technology developed by Nobel Prize winner Prof. Dr. Stefan Hell and his teams in Heidelberg and Göttingen, are now able to bypass this resolution limit and provide detailed insights into living cells in the lower nanometre range.

    https://biopro-v9-test-gi.xanium.io/en/article/news/micro-nanoscope
  • Project BlindZero - 03/08/2023 The two researchers in the laboratory in front of the 3D printer and with a Petri dish with the cornea in their hands.

    Hope for patients with eye diseases: human cornea from 3D printers

    Thousands of cornea transplants are performed every year. However, donors are rare and the procedure is not always without complications. Researchers at the University of Heidelberg are developing an innovative technique in the project BlindZero. It involves ‘printing’ human corneas directly onto patients’ eyes using 3D bioprinting. The reprogrammed genetically engineered cells used for this purpose are not expected to cause a rejection reaction.

    https://biopro-v9-test-gi.xanium.io/en/article/news/hope-patients-eye-diseases-human-cornea-3d-printers
  • Tumour organoids facilitate drug discovery - 20/07/2023 A woman in a white lab coat is sitting at a computer whose screen shows various miniature tumors after drug treatment.

    Drug screening for children with cancer using patient-specific miniature tumours

    Standard drugs often don’t work in children and adolescents with recurrent cancer. Researchers from the Hopp Children's Tumour Centre (KITZ) and the German Cancer Research Center (DKFZ) in Heidelberg have been looking to open up new therapy options for those affected, and have cultivated individual miniature tumours from biopsy samples to test the effectiveness of a variety of drugs within a few weeks.

    https://biopro-v9-test-gi.xanium.io/en/article/news/drug-screening-children-cancer-using-patient-specific-miniature-tumours
  • Press release - 03/07/2023

    The sacrifice within – how collagen’s weak bonds help protect tissue

    HITS researchers publish new findings on collagen, the most abundant protein in our body: So-called “sacrificial bonds” in collagen break faster than the basic structure and thus protect the tissue as a whole because they track down harmful radicals that are produced during mechanical stress. The work was published in “Nature Communications.”

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/sacrifice-within-how-collagens-weak-bonds-help-protect-tissue
  • Press release - 21/03/2022

    BMBF funds Heidelberg Junior Research Group for 3D Bioprinting Project

    Junior Professor Dr Daniela Duarte Campos has been awarded a substantial grant from the Federal Ministry of Education and Research (BMBF). She and her junior research group are investigating bioprinting for tissue and organ engineering at the Center for Molecular Biology of Heidelberg University and at the “3D Matter Made to Order” Cluster of Excellence, a collaboration between Ruperto Carola and Karlsruhe Institute of Technology (KIT).

    https://biopro-v9-test-gi.xanium.io/en/article/press-release/bmbf-funds-heidelberg-junior-research-group-3d-bioprinting-project
  • Article - 10/03/2021 Bild2-Mahlwerk.JPG

    Faster to single cells using miniature grinder

    Tissue cells are needed for medical diagnostics, cell therapies and tissue engineering, among other things. A novel tissue grinder gently and automatically dissociates cells from tissue. In November 2020, the newly founded biotech company Fast Forward Discoveries GmbH (FFX) delivered its first tissue grinders to customers.

    https://biopro-v9-test-gi.xanium.io/en/article/news/faster-single-cells-using-miniature-grinder
  • Dossier - 12/03/2012 One hand holds a cell culture plate with six different cell cultures

    Regenerative medicine makes use of patients own resources

    Die Regenerative Medizin bietet neue Therapieoptionen quer durch die ärztlichen Fachgebiete. Zumeist sind es zellbasierte Verfahren und sie werden häufig mit innovativen Biomaterialien kombiniert. Regenerative Therapien vereinen Know-how aus den Biowissenschaften mit moderner Medizintechnik und sie profitieren von den Fortschritten in den Ingenieur- und Materialwissenschaften.

    https://biopro-v9-test-gi.xanium.io/en/article/dossier/regenerative-medicine-makes-use-of-patients-own-resources
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